The link between age-related dental syndromes and some oral predictors of ageing

Relevance. Ageing is an important factor causing various diseases and functional failure. markers help to characterize the ageing process comprehensively. Currently, molecular genetic human are most promising (Molecular / DNA-Based Markers).The study aimed identify relationship between age-related dental syndromes some oral predictors of ageing. Materials methods. The included 200 elderly patients, aged 60-74 years, according WHO classification. patients were divided into 3 groups based on detected clinical syndrome (occlusive, periodontal, dystrophic). In all we collected non-stimulated fluid. fluid immunochemical examination determined BCL-2 (B Cell Lymphoma 2), Caspase 3, Cytochrome C, GAPDH (Glyceraldehyde 3-Phosphate Dehydrogenase), Cleaved PARP (Poly (ADP-ribose) polymerase) p53, using method multi-parametric fluorescent analysis with magnetic microspheres. Results. According study, dystrophic demonstrated highest concentration apoptosis markers, occlusal – lowest. Periodontal exhibited a moderate level predictors. Conclusion. Determining marker in may have practical use customized diagnosis predisposition principal syndromes, as well systemic comorbidity. Early at initial stage allows us give timely recommendations correct their lifestyle, habits, medication intake.